CROT

Across TCGA patient cohorts, CROT mutation is significantly associated with the RNA expression of many other genes, with 3,238 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CROT-associated genes across cancer lineages are EIF4A1P3, SULT6B1, and MTCYBP36. Each is linked with CROT in more than 2 cancer types. Because this analysis shows association rather than direction, both CROT-to-partner and partner-to-CROT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4A1P3 grouped by CROT-low versus CROT-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CROT→partner) and Y-score (partner→CROT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF4A1P3 →	+0.291	+3.993	<.001	.005	3	3
READ	SULT6B1 →	+0.042	+3.827	.002	.006	3	2
READ	MTCYBP36 →	+0.094	+4.672	<.001	.004	3	2
READ	DEFB109A →	+0.421	+4.023	<.001	.005	3	2
READ	RNU6-781P →	+0.760	+4.341	<.001	.007	3	2
READ	MIR4462 →	+0.526	+5.691	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,238 associations by consensus.

EIF4A1P3 by CROT expression — COAD

Explore this box plot interactively →