CROT

Across TCGA cell cohorts, CROT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,272 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CROT-associated GO terms across cancer lineages are Endosomal transport, Carnitine metabolic process, and Medium-chain fatty acid metabolic process. Each is linked with CROT in more than 10 cancer types. Because this analysis shows association rather than direction, both CROT-to-partner and partner-to-CROT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by CROT-low versus CROT-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CROT→partner) and Y-score (partner→CROT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endosomal transport →	+0.048	+0.644	.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Carnitine metabolic process →	+0.108	+1.006	.002	.003	3	10
SKIN	Medium-chain fatty acid metabolic process →	+0.146	+1.079	<.001	<.001	3	10
CNS	Amino-acid betaine metabolic process →	+0.123	+1.098	<.001	.002	3	10
BLOOD_Leukemia	Vesicle-mediated transport between endosomal compartments →	+0.052	+1.073	<.001	<.001	3	9
BLOOD_Leukemia	Early endosome to late endosome transport →	+0.052	+1.073	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,272 associations by consensus.

Endosomal transport by CROT expression — BONE

Explore this box plot interactively →