CROT

Across TCGA cell cohorts, CROT mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CROT-associated genes across cancer lineages are ZC2HC1B, IL36B, and UGT2B17. Each is linked with CROT in more than 1 cancer types. Because this analysis shows association rather than direction, both CROT-to-partner and partner-to-CROT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZC2HC1B grouped by CROT-low versus CROT-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CROT→partner) and Y-score (partner→CROT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZC2HC1B →	+0.026	+3.405	<.001	.005	3	1
OVARY	IL36B →	+0.090	+3.974	.002	.002	3	1
OVARY	UGT2B17 →	+0.111	+3.263	.001	.006	3	1
LUNG_NSCLC_LUAD	LUZP4 →	+0.052	+4.215	<.001	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.705	+3.474	<.001	.003	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ZC2HC1B by CROT expression — OVARY

Explore this box plot interactively →