CROCC

Across TCGA patient cohorts, CROCC mutation is significantly associated with the RNA expression of many other genes, with 7,403 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CROCC-associated genes across cancer lineages are GEMIN2, RNF138, and RBBP4. Each is linked with CROCC in more than 4 cancer types. Because this analysis shows association rather than direction, both CROCC-to-partner and partner-to-CROCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GEMIN2 grouped by CROCC-low versus CROCC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CROCC→partner) and Y-score (partner→CROCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GEMIN2 →	+0.766	+3.497	<.001	.002	3	5
SKCM	RNF138 →	+0.783	+3.839	.001	<.001	3	5
SKCM	RBBP4 →	+0.608	+3.813	.001	<.001	3	5
SKCM	LRRC40 →	+1.044	+3.826	<.001	<.001	3	5
SKCM	RPF1 →	+0.636	+3.813	.001	<.001	3	5
SKCM	SEH1L →	+0.613	+3.478	.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,403 associations by consensus.

GEMIN2 by CROCC expression — SKCM

Explore this box plot interactively →