CROCC

Across TCGA patient cohorts, CROCC mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CROCC-associated genes across cancer lineages are Cyclin-B1, Notch1, and TAZ. Each is linked with CROCC in more than 3 cancer types. Because this analysis shows association rather than direction, both CROCC-to-partner and partner-to-CROCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CROCC-low versus CROCC-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CROCC→partner) and Y-score (partner→CROCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-B1 →	+0.619	+3.000	.009	.034	2	4
COAD	Notch1 →	+0.143	+1.330	.025	.045	3	3
COAD	TAZ →	+0.174	+2.112	.010	.003	3	3
COAD	ASNS →	+0.547	+2.593	<.001	<.001	3	3
UCEC	ATM →	-0.530	-2.000	<.001	<.001	3	3
UCEC	VHL →	-0.719	-1.847	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Cyclin-B1 by CROCC expression — STAD

Explore this box plot interactively →