CROCC

Across TCGA cell cohorts, CROCC mutation is significantly associated with the RNA expression of many other genes, with 1,127 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CROCC-associated genes across cancer lineages are SRD5A1, ZW10, and SDHB. Each is linked with CROCC in more than 2 cancer types. Because this analysis shows association rather than direction, both CROCC-to-partner and partner-to-CROCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRD5A1 grouped by CROCC-low versus CROCC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CROCC→partner) and Y-score (partner→CROCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SRD5A1 →	+0.663	+3.115	.003	.009	3	3
LUNG_NSCLC_LUAD	ZW10 →	+0.454	+3.169	.004	.008	3	3
LARGE_INTESTINE	SDHB →	+0.401	+2.451	.005	<.001	3	3
LARGE_INTESTINE	AGL →	+0.602	+3.321	.001	.003	3	3
LARGE_INTESTINE	RNASEH1 →	+0.455	+1.850	<.001	.006	3	3
LARGE_INTESTINE	EIF3I →	+0.330	+3.169	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,127 associations by consensus.

SRD5A1 by CROCC expression — BLOOD_Leukemia

Explore this box plot interactively →