CRNN

Across TCGA patient cohorts, CRNN RNA expression is significantly associated with the go_rna of many other GO terms, with 5,760 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRNN-associated GO terms across cancer lineages are Protein nitrosylation, Positive regulation of epidermis development, and Epidermal cell differentiation. Each is linked with CRNN in more than 8 cancer types. Because this analysis shows association rather than direction, both CRNN-to-partner and partner-to-CRNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein nitrosylation grouped by CRNN-low versus CRNN-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRNN→partner) and Y-score (partner→CRNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein nitrosylation →	+0.056	+3.003	.001	<.001	3	9
ESCA	Positive regulation of epidermis development →	+0.063	+2.584	<.001	.002	3	9
ESCA	Epidermal cell differentiation →	+0.060	+4.279	<.001	<.001	3	8
ESCA	Regulation of keratinocyte proliferation →	+0.075	+3.723	<.001	<.001	3	8
ESCA	Peptide cross-linking →	+0.116	+4.267	<.001	<.001	3	8
STAD	Keratinocyte proliferation →	+0.063	+1.270	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,760 associations by consensus.

Protein nitrosylation by CRNN expression — ESCA

Explore this box plot interactively →