CRNN

Across TCGA patient cohorts, CRNN mutation is significantly associated with the RNA expression of many other genes, with 1,245 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CRNN-associated genes across cancer lineages are ACO2, AAGAB, and OR10R3P. Each is linked with CRNN in more than 2 cancer types. Because this analysis shows association rather than direction, both CRNN-to-partner and partner-to-CRNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACO2 grouped by CRNN-low versus CRNN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRNN→partner) and Y-score (partner→CRNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACO2 →	+0.473	+2.143	.002	<.001	3	3
UCEC	AAGAB →	+0.431	+3.343	.007	.005	3	3
STAD	OR10R3P →	+0.118	+3.830	.001	.006	3	3
SKCM	CENPN →	+0.425	+2.028	.009	.005	3	3
SKCM	METTL2A →	+0.345	+2.177	.006	.008	3	3
UCEC	ALDOA →	+0.525	+2.724	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,245 associations by consensus.

ACO2 by CRNN expression — SKCM

Explore this box plot interactively →