CRNN

Across TCGA patient cohorts, CRNN mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRNN-associated genes across cancer lineages are p62 Lck ligand, 53BP1, and eIF4E. Each is linked with CRNN in more than 2 cancer types. Because this analysis shows association rather than direction, both CRNN-to-partner and partner-to-CRNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CRNN-low versus CRNN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRNN→partner) and Y-score (partner→CRNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.441	+2.179	.003	.034	3	3
LUSC	53BP1 →	+0.494	+2.816	.031	.036	3	2
SKCM	eIF4E →	+0.182	+3.000	.005	<.001	3	2
SKCM	GAPDH →	+0.540	+2.459	.013	.017	3	2
SKCM	4E-BP1 →	+0.256	+1.874	.024	.049	3	2
UCEC	PKC-delta_pS664 →	-0.138	-2.312	.013	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by CRNN expression — UCEC

Explore this box plot interactively →