CRLS1

Across TCGA patient cohorts, CRLS1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRLS1-associated genes across cancer lineages are A-Raf_pS299, VHL, and NDRG1_pT346. Each is linked with CRLS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRLS1-to-partner and partner-to-CRLS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CRLS1-low versus CRLS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRLS1→partner) and Y-score (partner→CRLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.140	-3.169	.015	.019	3	1
UCEC	VHL →	-1.345	-3.459	<.001	.005	3	1
UCEC	NDRG1_pT346 →	-0.592	-3.169	.012	.019	2	1
UCEC	ERK2 →	+0.185	+3.584	.046	.002	1	1
UCEC	p62 Lck ligand →	+0.421	+3.584	.007	.002	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

A-Raf_pS299 by CRLS1 expression — UCEC

Explore this box plot interactively →