CRLS1

Across TCGA pan-cancer cohorts, CRLS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CRLS1 data layer compared with 4 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CRLS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CRLS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and READ show a favorable association.

UVM, LUAD, and CHOL are the cancer types where CRLS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.312	0.823	<.001	63	view →
LUAD	OS	Quartile	II,III,IV	0.851	0.615	<.001	46	view →
CHOL	OS	Tertile	All	0.368	0.956	.001	44	view →
KICH	DFS	Median	III,IV	0.240	1.000	.001	38	view →
KIRC	DFS	Median	II,III,IV	0.725	0.868	.007	37	view →
PAAD	DFS	Tertile	All	0.240	0.548	.001	27	view →
HNSC	OS	Median	II,III,IV	0.618	0.789	.009	23	view →
MESO	DFS	Median	III,IV	0.170	0.660	<.001	21	view →
SARC	OS	Median	All	0.442	0.724	<.001	21	view →
LUSC	DFS	Quartile	II,III,IV	0.466	0.713	.001	19	view →
READ	OS	Quartile	All	1.000	0.801	.007	16	view →
COAD	DFS	Median	All	0.454	0.639	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CRLS1–UVM (DFS)

Open the UVM breakdown →