CRLS1

Across TCGA cell cohorts, CRLS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,714 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRLS1-associated GO terms across cancer lineages are Regulation of peroxisome organization, Phosphatidylglycerol biosynthetic process, and Negative regulation of appetite by leptin-mediated signaling pathway. Each is linked with CRLS1 in more than 8 cancer types. Because this analysis shows association rather than direction, both CRLS1-to-partner and partner-to-CRLS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of peroxisome organization grouped by CRLS1-low versus CRLS1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRLS1→partner) and Y-score (partner→CRLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of peroxisome organization →	+0.124	+0.434	.004	.001	3	8
PANCREAS	Phosphatidylglycerol biosynthetic process →	+0.103	+0.775	.001	.003	2	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of appetite by leptin-mediated signaling pathway →	+0.142	+0.815	<.001	.002	3	8
STOMACH	Regulation of translational elongation →	-0.061	-0.711	.006	<.001	3	7
BLOOD_Lymphoma	mRNA pseudouridine synthesis →	+0.069	+0.478	<.001	.002	3	7
LIVER	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	-0.270	-0.507	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,714 associations by consensus.

Regulation of peroxisome organization by CRLS1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →