CRKL

Across TCGA patient cohorts, CRKL RNA expression is significantly associated with the protein abundance of many other proteins, with 16,664 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CRKL-associated proteins across cancer lineages are TRMT2A, ESS2, and RANBP1. Each is linked with CRKL in more than 5 cancer types. Because this analysis shows association rather than direction, both CRKL-to-partner and partner-to-CRKL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CRKL versus TRMT2A in LSCC, with a Pearson correlation of 0.65.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CRKL→partner) and Y-score (partner→CRKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRMT2A →	+0.330	+0.716	<.001	<.001	3	6
GBM	ESS2 →	+0.249	+0.322	<.001	<.001	3	5
LSCC	RANBP1 →	+0.512	+0.782	<.001	<.001	3	5
GBM	BCR →	+0.383	+0.303	<.001	<.001	3	4
OV	CHEK2_S379 →	+1.070	+0.616	<.001	.001	3	4
GBM	XRCC6 →	+0.251	+0.260	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,664 associations by consensus.

CRKL vs TRMT2A — LSCC

Explore this scatter interactively →