CRKL

Across TCGA patient cohorts, CRKL protein abundance is significantly associated with the RNA expression of many other genes, with 11,244 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CRKL-associated genes across cancer lineages are SNAP29, UBE2L3, and ASCC2. Each is linked with CRKL in more than 7 cancer types. Because this analysis shows association rather than direction, both CRKL-to-partner and partner-to-CRKL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CRKL versus SNAP29 in LSCC, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRKL→partner) and Y-score (partner→CRKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SNAP29 →	+0.470	+0.260	<.001	<.001	3	8
OV	UBE2L3 →	+0.504	+0.186	<.001	<.001	3	6
LSCC	ASCC2 →	+0.465	+0.311	<.001	<.001	3	6
BRCA	TFIP11 →	+0.418	+0.188	<.001	<.001	3	5
OV	PEX26 →	+0.487	+0.306	<.001	<.001	3	5
BRCA	TMEM191A →	+0.476	+0.196	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,244 associations by consensus.

CRKL vs SNAP29 — LSCC

Explore this scatter interactively →