CRKL

Across TCGA patient cohorts, CRKL mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRKL-associated genes across cancer lineages are Shc_pY317, ERK2, and JNK2. Each is linked with CRKL in more than 1 cancer types. Because this analysis shows association rather than direction, both CRKL-to-partner and partner-to-CRKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by CRKL-low versus CRKL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRKL→partner) and Y-score (partner→CRKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.140	-2.115	.016	.017	3	2
UCEC	ERK2 →	+0.177	+2.000	.016	.030	3	1
UCEC	JNK2 →	+0.256	+3.196	<.001	.009	3	1
UCEC	Ku80 →	+0.250	+1.710	.005	.025	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.420	-3.169	.014	.018	3	1
UCEC	PDCD4 →	-0.433	-1.678	.016	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Shc_pY317 by CRKL expression — UCEC

Explore this box plot interactively →