CRKL

Across TCGA cell cohorts, CRKL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,952 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRKL-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Protein modification by small protein removal. Each is linked with CRKL in more than 19 cancer types. Because this analysis shows association rather than direction, both CRKL-to-partner and partner-to-CRKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by CRKL-low versus CRKL-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRKL→partner) and Y-score (partner→CRKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Symbiont-mediated disruption of host cellular anatomical structure →	+0.156	+1.489	<.001	<.001	3	20
STOMACH	Symbiont-mediated disruption of host anatomical structure →	+0.156	+1.489	<.001	<.001	3	20
BREAST	Protein modification by small protein removal →	+0.046	+0.778	.002	.006	2	17
BONE	Negative regulation of gene expression, epigenetic →	+0.071	+0.633	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Heterochromatin organization →	+0.069	+1.055	<.001	.001	3	15
BONE	Transcription elongation-coupled chromatin remodeling →	+0.105	+0.586	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,952 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by CRKL expression — STOMACH

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