CRISPLD1

Across TCGA cell cohorts, CRISPLD1 mutation is significantly associated with the RNA expression of many other genes, with 408 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRISPLD1-associated genes across cancer lineages are REG3A, CXorf65, and TAAR8. Each is linked with CRISPLD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRISPLD1-to-partner and partner-to-CRISPLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3A grouped by CRISPLD1-low versus CRISPLD1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISPLD1→partner) and Y-score (partner→CRISPLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REG3A →	+0.033	+4.421	<.001	.004	3	2
LUNG_NSCLC_LUSC	CXorf65 →	+0.092	+4.108	.001	.005	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.017	+4.662	<.001	.005	3	1
OVARY	MC2R →	+0.043	+5.807	<.001	.001	3	1
OVARY	KRTAP9-1 →	+0.090	+5.807	<.001	.001	3	1
BREAST	OR6F1 →	+0.079	+4.421	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 408 associations by consensus.

REG3A by CRISPLD1 expression — BREAST

Explore this box plot interactively →