CRISP3

Across TCGA pan-cancer cohorts, CRISP3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CRISP3 data layer compared with 18 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CRISP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CRISP3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and OV show a favorable association.

LUAD, CCRCC, and OV are the cancer types where CRISP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.333	0.811	<.001	28	view →
CCRCC	DFS	Tertile	IV	0.815	0.162	.024	6	view →
OV	DFS	Median	All	1.000	0.869	.042	4	view →
GBM	DFS	Tertile	All	0.493	0.235	.049	2	view →
LSCC	DFS	Tertile	All	0.742	0.353	.048	2	view →
HNSC	DFS	Tertile	III,IV	1.000	0.623	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CRISP3–LUAD (OS)

Open the LUAD breakdown →