CRISP3

Across TCGA pan-cancer cohorts, CRISP3 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CRISP3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CRISP3 RNA is repressed in tumor relative to normal tissue. In most cancer types CRISP3 is over-expressed in tumor, although a few such as HNSC and UCEC show the opposite, repressed pattern.

HNSC, UCEC, and LUAD are the cancer types where CRISP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRISP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	−6.260	<.001	12	view →
UCEC	All	All	−3.660	.002	6	view →
LUAD	Female	All	−0.682	<.001	6	view →
KICH	Male	IV	−0.066	<.001	6	view →
BRCA	Female	All	+0.808	.001	4	view →
THCA	Female	All	−0.030	.004	3	view →
PAAD	All	All	+3.235	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CRISP3–HNSC

Open the HNSC breakdown →