CRISP3

Across TCGA patient cohorts, CRISP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,504 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible CRISP3-associated GO terms across cancer lineages are PERK-mediated unfolded protein response, Tight junction organization, and Cellular response to hydroperoxide. Each is linked with CRISP3 in more than 11 cancer types. Because this analysis shows association rather than direction, both CRISP3-to-partner and partner-to-CRISP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PERK-mediated unfolded protein response grouped by CRISP3-low versus CRISP3-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISP3→partner) and Y-score (partner→CRISP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	PERK-mediated unfolded protein response →	+0.061	+1.625	<.001	.001	2	12
TGCT	Tight junction organization →	+0.051	+0.703	<.001	.001	3	11
TGCT	Cellular response to hydroperoxide →	+0.077	+0.516	<.001	<.001	3	10
TGCT	Tissue homeostasis →	+0.030	+0.792	<.001	<.001	3	10
UCEC	Obsolete ubiquitin-dependent ERAD pathway →	+0.029	+0.731	<.001	<.001	3	10
ESCA	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.039	+0.954	.001	.008	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,504 associations by consensus.

PERK-mediated unfolded protein response by CRISP3 expression — CHOL

Explore this box plot interactively →