CRISP3

Across TCGA patient cohorts, CRISP3 protein abundance is significantly associated with the RNA expression of many other genes, with 14,502 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CRISP3-associated genes across cancer lineages are CEACAM3, CXCR2, and HCAR2. Each is linked with CRISP3 in more than 8 cancer types. Because this analysis shows association rather than direction, both CRISP3-to-partner and partner-to-CRISP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CRISP3 versus CEACAM3 in LSCC, with a Pearson correlation of 0.80.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISP3→partner) and Y-score (partner→CRISP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CEACAM3 →	+0.967	+1.281	<.001	<.001	3	9
LSCC	CXCR2 →	+1.253	+1.027	<.001	<.001	3	8
COAD	HCAR2 →	+1.576	+0.975	<.001	<.001	3	8
LSCC	ADGRG3 →	+1.132	+1.209	<.001	<.001	3	8
COAD	FCAR →	+0.916	+1.330	<.001	<.001	3	8
HNSC	MEFV →	+0.947	+0.605	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,502 associations by consensus.

CRISP3 vs CEACAM3 — LSCC

Explore this scatter interactively →