CRISP3

Across TCGA cell cohorts, CRISP3 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CRISP3-associated genes across cancer lineages are GFRA4, CCL21, and PRAMEF10. Each is linked with CRISP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRISP3-to-partner and partner-to-CRISP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by CRISP3-low versus CRISP3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISP3→partner) and Y-score (partner→CRISP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GFRA4 →	+0.250	+4.087	<.001	.002	3	1
LUNG_SCLC	CCL21 →	+0.035	+4.256	.003	.002	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	OR5H2 →	+0.030	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF20 →	+0.300	+4.684	<.001	<.001	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GFRA4 by CRISP3 expression — LUNG_SCLC

Explore this box plot interactively →