CRISP1

Across TCGA patient cohorts, CRISP1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRISP1-associated genes across cancer lineages are ACVRL1, Caveolin-1, and Smac. Each is linked with CRISP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRISP1-to-partner and partner-to-CRISP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by CRISP1-low versus CRISP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISP1→partner) and Y-score (partner→CRISP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.201	-2.986	.003	.035	3	2
UCEC	Caveolin-1 →	-0.822	-3.000	.024	.036	3	2
SKCM	Smac →	+0.371	+2.476	.004	.010	3	1
SKCM	Smad4 →	+0.230	+3.204	<.001	.008	3	1
SKCM	Src →	-0.282	-2.459	.010	.020	3	1
UCEC	A-Raf_pS299 →	-0.232	-3.000	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ACVRL1 by CRISP1 expression — UCEC

Explore this box plot interactively →