CRISP1

Across TCGA pan-cancer cohorts, CRISP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CRISP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CRISP1 RNA is repressed in tumor relative to normal tissue. In most cancer types CRISP1 is over-expressed in tumor, although a few such as KIRC and PRAD show the opposite, repressed pattern.

KIRC, BRCA, and PRAD are the cancer types where CRISP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRISP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.041	.001	7	view →
BRCA	Female	II,III,IV	+0.108	<.001	6	view →
PRAD	All	All	−1.058	.001	2	view →
KICH	Female	All	−0.046	.022	2	view →
KIRP	Male	All	−0.020	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CRISP1–KIRC

Open the KIRC breakdown →