CRIM1-DT

Across TCGA pan-cancer cohorts, CRIM1-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CRIM1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CRIM1-DT RNA is repressed in tumor relative to normal tissue. In most cancer types CRIM1-DT is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and THCA are the cancer types where CRIM1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRIM1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.874	<.001	11	view →
LUAD	Female	III,IV	−1.683	<.001	9	view →
THCA	Male	IV	−1.480	.002	9	view →
KICH	Female	II,III,IV	−2.287	<.001	8	view →
LIHC	All	II,III,IV	+1.629	<.001	8	view →
READ	All	All	−1.250	.001	7	view →
BRCA	All	II,III,IV	−1.536	<.001	6	view →
UCEC	All	All	−1.410	<.001	6	view →
CHOL	Female	All	+4.320	<.001	5	view →
PRAD	All	All	−0.813	<.001	2	view →
PAAD	All	All	−0.317	.044	2	view →
BLCA	Female	IV	+1.143	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CRIM1-DT–COAD

Open the COAD breakdown →