CRHR2

Across TCGA cell cohorts, CRHR2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CRHR2-associated genes across cancer lineages are VN1R4, SLC15A5, and PNLIPRP3. Each is linked with CRHR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRHR2-to-partner and partner-to-CRHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R4 grouped by CRHR2-low versus CRHR2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRHR2→partner) and Y-score (partner→CRHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VN1R4 →	+0.073	+4.754	<.001	.005	3	1
LUNG_SCLC	SLC15A5 →	+0.038	+4.269	<.001	.005	3	1
LUNG_SCLC	PNLIPRP3 →	+0.011	+4.523	.002	.003	3	1
LUNG_NSCLC_LUAD	OR1E2 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.048	+4.887	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

VN1R4 by CRHR2 expression — CNS

Explore this box plot interactively →