CRH

Across TCGA patient cohorts, CRH RNA expression is significantly associated with the go_rna of many other GO terms, with 6,763 significant associations in total. LGG shows the largest number of these associations.

The most reproducible CRH-associated GO terms across cancer lineages are Regulation of dendritic spine development, Regulation of neuron differentiation, and Regulation of blood circulation. Each is linked with CRH in more than 9 cancer types. Because this analysis shows association rather than direction, both CRH-to-partner and partner-to-CRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of dendritic spine development grouped by CRH-low versus CRH-high in LGG.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRH→partner) and Y-score (partner→CRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	Regulation of dendritic spine development →	+0.041	+0.996	<.001	<.001	3	10
TGCT	Regulation of neuron differentiation →	+0.031	+0.441	<.001	<.001	3	8
UCS	Regulation of blood circulation →	+0.026	+0.695	<.001	<.001	3	8
TGCT	Kidney epithelium development →	+0.045	+0.309	<.001	<.001	3	8
STAD	Mitochondrial membrane organization →	+0.051	+0.164	<.001	<.001	3	7
TGCT	Cardiac septum morphogenesis →	+0.057	+0.308	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,763 associations by consensus.

Regulation of dendritic spine development by CRH expression — LGG

Explore this box plot interactively →