CRH

Across TCGA pan-cancer cohorts, CRH RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CRH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CRH RNA is repressed in tumor relative to normal tissue. In most cancer types CRH is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where CRH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.201	<.001	11	view →
LUAD	All	All	−0.432	<.001	7	view →
LUSC	All	All	−0.285	<.001	6	view →
THCA	Female	All	+0.085	<.001	3	view →
KIRP	All	All	−0.195	.001	2	view →
KICH	All	All	+1.248	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

CRH–KIRC

Open the KIRC breakdown →