CRH

Across TCGA patient cohorts, CRH protein abundance is significantly associated with the RNA expression of many other genes, with 1,548 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CRH-associated genes across cancer lineages are TREML2, CD1D, and IL6R. Each is linked with CRH in more than 1 cancer types. Because this analysis shows association rather than direction, both CRH-to-partner and partner-to-CRH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CRH versus TREML2 in GBM, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRH→partner) and Y-score (partner→CRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TREML2 →	+0.953	+0.874	.001	<.001	3	2
GBM	CD1D →	+0.915	+0.693	.002	.003	3	2
GBM	IL6R →	+1.154	+0.573	<.001	.008	3	2
GBM	RN7SL288P →	+1.406	+0.719	<.001	<.001	3	2
BRCA	SLC38A7 →	-0.727	-1.497	<.001	.002	3	1
BRCA	USP31 →	-0.827	-1.497	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,548 associations by consensus.

CRH vs TREML2 — GBM

Explore this scatter interactively →