CREM

Across TCGA patient cohorts, CREM protein abundance is significantly associated with the RNA expression of many other genes, with 2,224 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CREM-associated genes across cancer lineages are PXMP4, MED7, and TMEM9B. Each is linked with CREM in more than 2 cancer types. Because this analysis shows association rather than direction, both CREM-to-partner and partner-to-CREM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CREM versus PXMP4 in BRCA, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREM→partner) and Y-score (partner→CREM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PXMP4 →	-1.189	-0.396	.002	.001	3	3
LUAD	MED7 →	-0.466	-0.359	.001	.001	3	2
LUAD	TMEM9B →	-0.550	-0.315	.001	.008	3	2
PDAC	RNU2-58P →	-1.010	-0.517	<.001	<.001	3	2
LUAD	IGHV4-55 →	+1.415	+0.315	.001	<.001	3	2
GBM	ZNF2 →	-0.504	-0.832	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,224 associations by consensus.

CREM vs PXMP4 — BRCA

Explore this scatter interactively →