CREM

Across TCGA patient cohorts, CREM mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREM-associated genes across cancer lineages are EGFR_pY1068, PCNA, and PKC-b-II_pS660. Each is linked with CREM in more than 2 cancer types. Because this analysis shows association rather than direction, both CREM-to-partner and partner-to-CREM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CREM-low versus CREM-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREM→partner) and Y-score (partner→CREM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.419	-3.000	.004	.034	3	2
COAD	PCNA →	+0.318	+3.182	.004	.009	3	2
COAD	PKC-b-II_pS660 →	-0.531	-3.450	<.001	.005	3	2
COAD	Shc_pY317 →	-0.196	-2.983	.009	.034	3	2
UCEC	ATM →	-0.561	-2.087	<.001	.005	3	2
COAD	Caspase-7-cleavedD198 →	+1.316	+3.321	<.001	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

EGFR_pY1068 by CREM expression — COAD

Explore this box plot interactively →