CREM

Across TCGA cell cohorts, CREM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,084 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CREM-associated GO terms across cancer lineages are Cell junction assembly, CAMP/PKA signal transduction, and Protein localization to cell surface. Each is linked with CREM in more than 9 cancer types. Because this analysis shows association rather than direction, both CREM-to-partner and partner-to-CREM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell junction assembly grouped by CREM-low versus CREM-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CREM→partner) and Y-score (partner→CREM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cell junction assembly →	-0.074	-1.307	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	CAMP/PKA signal transduction →	+0.207	+1.607	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Protein localization to cell surface →	-0.101	-0.954	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Homophilic cell-cell adhesion →	-0.155	-1.312	.005	.002	3	8
STOMACH	Cell-cell junction organization →	-0.078	-0.798	<.001	.004	3	8
BREAST	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.080	+0.671	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,084 associations by consensus.

Cell junction assembly by CREM expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →