CREM

Across TCGA cell cohorts, CREM mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CREM-associated genes across cancer lineages are ZAN, OR14A16, and RASSF9. Each is linked with CREM in more than 1 cancer types. Because this analysis shows association rather than direction, both CREM-to-partner and partner-to-CREM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by CREM-low versus CREM-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREM→partner) and Y-score (partner→CREM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZAN →	+0.023	+3.954	.005	.005	3	1
BLOOD_Lymphoma	OR14A16 →	+0.009	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	RASSF9 →	+0.121	+4.169	<.001	.003	3	1
BLOOD_Lymphoma	KRT40 →	+0.388	+4.070	<.001	.004	3	1
BLOOD_Lymphoma	POTEB3 →	+0.081	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	FKBP6 →	+0.049	+4.321	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ZAN by CREM expression — BLOOD_Lymphoma

Explore this box plot interactively →