CRELD1

Across TCGA patient cohorts, CRELD1 mutation is significantly associated with the RNA expression of many other genes, with 409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRELD1-associated genes across cancer lineages are HSBP1P2, PINCR, and CCDC137P. Each is linked with CRELD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRELD1-to-partner and partner-to-CRELD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSBP1P2 grouped by CRELD1-low versus CRELD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRELD1→partner) and Y-score (partner→CRELD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSBP1P2 →	+0.418	+2.278	.006	.006	3	2
COAD	PINCR →	+0.413	+3.798	<.001	.009	3	2
COAD	CCDC137P →	+0.261	+4.289	<.001	.003	3	2
UCEC	RALBP1P2 →	+0.110	+1.846	.008	.004	3	2
UCEC	GPATCH11 →	+0.419	+2.732	.005	.003	3	1
UCEC	DDAH1 →	+0.721	+3.343	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 409 associations by consensus.

HSBP1P2 by CRELD1 expression — UCEC

Explore this box plot interactively →