CREBRF

Across TCGA patient cohorts, CREBRF mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREBRF-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Notch1, and Caspase-7-cleavedD198. Each is linked with CREBRF in more than 3 cancer types. Because this analysis shows association rather than direction, both CREBRF-to-partner and partner-to-CREBRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by CREBRF-low versus CREBRF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREBRF→partner) and Y-score (partner→CREBRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.427	-1.678	.004	.021	3	4
UCEC	Notch1 →	+0.170	+2.428	<.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.807	+2.522	<.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.223	-2.999	<.001	<.001	3	2
UCEC	JNK2 →	+0.303	+3.058	<.001	<.001	3	2
UCEC	PCNA →	+0.278	+2.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

p38-MAPK_pT180_Y182 by CREBRF expression — UCEC

Explore this box plot interactively →