CREBRF

Across TCGA pan-cancer cohorts, CREBRF RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CREBRF’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CREBRF RNA is repressed in tumor relative to normal tissue. In most cancer types CREBRF is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.

LUAD, UCEC, and LUSC are the cancer types where CREBRF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CREBRF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.054	<.001	11	view →
UCEC	All	All	−1.837	<.001	8	view →
LUSC	Female	II,III,IV	−1.352	<.001	8	view →
BLCA	All	All	−0.790	.003	8	view →
THCA	Male	All	−0.764	<.001	8	view →
BRCA	Female	All	−0.709	<.001	6	view →
COAD	Female	All	−0.879	<.001	4	view →
CHOL	All	All	+0.955	<.001	3	view →
READ	All	All	−0.718	.029	3	view →
PRAD	All	All	−0.290	.005	2	view →
LIHC	All	All	+0.262	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CREBRF–LUAD

Open the LUAD breakdown →