CREBRF

Across TCGA cell cohorts, CREBRF mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CREBRF-associated genes across cancer lineages are ITGAD, MOG, and PTTG2. Each is linked with CREBRF in more than 1 cancer types. Because this analysis shows association rather than direction, both CREBRF-to-partner and partner-to-CREBRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by CREBRF-low versus CREBRF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREBRF→partner) and Y-score (partner→CREBRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.013	+4.095	<.001	<.001	3	1
LARGE_INTESTINE	MOG →	+0.091	+3.639	.002	<.001	3	1
LARGE_INTESTINE	PTTG2 →	+0.074	+3.497	.003	.004	3	1
BREAST	DUSP29 →	+0.586	+5.781	<.001	.001	3	1
BLOOD_Leukemia	GRM5 →	+0.037	+4.060	<.001	.003	3	1
BLOOD_Leukemia	AQP12A →	+0.079	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ITGAD by CREBRF expression — LARGE_INTESTINE

Explore this box plot interactively →