CREBL2

Across TCGA patient cohorts, CREBL2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREBL2-associated genes across cancer lineages are eEF2, eIF4G, and A-Raf_pS299. Each is linked with CREBL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREBL2-to-partner and partner-to-CREBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CREBL2-low versus CREBL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREBL2→partner) and Y-score (partner→CREBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.371	+1.700	.014	.044	3	1
UCEC	eIF4G →	+0.291	+1.700	.027	.044	3	1
UCEC	A-Raf_pS299 →	-0.135	-2.321	.007	.034	3	1
UCEC	ERK2 →	+0.226	+3.169	.005	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.125	-2.222	.018	.011	3	1
UCEC	GAPDH →	+0.523	+2.321	.021	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by CREBL2 expression — UCEC

Explore this box plot interactively →