CREBL2

Across TCGA pan-cancer cohorts, CREBL2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CREBL2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CREBL2 RNA is repressed in tumor relative to normal tissue. In most cancer types CREBL2 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and THCA are the cancer types where CREBL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CREBL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.864	<.001	8	view →
LUAD	Female	III,IV	−0.996	<.001	7	view →
THCA	Male	All	−0.482	<.001	7	view →
UCEC	All	All	−1.399	<.001	6	view →
BLCA	Male	All	−0.585	.001	6	view →
BRCA	All	All	−0.547	<.001	6	view →
COAD	All	All	−0.338	.003	4	view →
CHOL	All	All	+0.994	<.001	3	view →
KICH	All	All	−0.577	.003	3	view →
HNSC	All	All	+0.332	.026	3	view →
KIRC	All	All	+0.201	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CREBL2–LUSC

Open the LUSC breakdown →