CREB5

Across TCGA cell cohorts, CREB5 mutation is significantly associated with the RNA expression of many other genes, with 450 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CREB5-associated genes across cancer lineages are CTXN3, RDH8, and OR5AR1. Each is linked with CREB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREB5-to-partner and partner-to-CREB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTXN3 grouped by CREB5-low versus CREB5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB5→partner) and Y-score (partner→CREB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CTXN3 →	+0.012	+5.201	<.001	.006	3	1
BLOOD_Leukemia	RDH8 →	+0.031	+5.201	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR5AR1 →	+0.026	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR5M1 →	+0.034	+4.266	<.001	.004	3	1
LARGE_INTESTINE	MIOX →	+0.417	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CGRRF1 →	+0.599	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 450 associations by consensus.

CTXN3 by CREB5 expression — BLOOD_Leukemia

Explore this box plot interactively →