CREB3L3

Across TCGA patient cohorts, CREB3L3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREB3L3-associated genes across cancer lineages are PCNA, HSP70, and EGFR_pY1068. Each is linked with CREB3L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREB3L3-to-partner and partner-to-CREB3L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CREB3L3-low versus CREB3L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB3L3→partner) and Y-score (partner→CREB3L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.262	+2.459	.012	.020	3	2
LUSC	HSP70 →	-0.548	-3.000	.028	.035	3	1
SKCM	EGFR_pY1068 →	+0.195	+1.891	.009	.030	3	1
SKCM	ACC1 →	+0.315	+2.334	.028	.018	3	1
UCEC	ERK2 →	+0.249	+2.459	.007	.020	3	1
UCEC	MEK1 →	+0.537	+2.459	.002	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PCNA by CREB3L3 expression — UCEC

Explore this box plot interactively →