CREB3L3

Across TCGA cell cohorts, CREB3L3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CREB3L3-associated genes across cancer lineages are OXT, CST4, and PAX4. Each is linked with CREB3L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREB3L3-to-partner and partner-to-CREB3L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by CREB3L3-low versus CREB3L3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB3L3→partner) and Y-score (partner→CREB3L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXT →	+0.044	+3.562	<.001	.002	3	1
SKIN	CST4 →	+0.252	+2.938	.001	.007	3	1
SKIN	PAX4 →	+0.019	+3.297	<.001	.002	3	1
SKIN	IFNA8 →	+0.020	+3.562	<.001	.002	3	1
SKIN	C5AR2 →	+0.052	+4.000	.006	.001	3	1
SKIN	PDE6H →	+0.116	+3.242	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OXT by CREB3L3 expression — SKIN

Explore this box plot interactively →