CREB1

Across TCGA patient cohorts, CREB1 mutation is significantly associated with the RNA expression of many other genes, with 558 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREB1-associated genes across cancer lineages are RNU6-751P, MRPS5P4, and OR7E156P. Each is linked with CREB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREB1-to-partner and partner-to-CREB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-751P grouped by CREB1-low versus CREB1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB1→partner) and Y-score (partner→CREB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-751P →	+0.518	+7.930	<.001	.008	3	2
SKCM	MRPS5P4 →	+0.139	+7.816	<.001	.008	3	2
BRCA	OR7E156P →	+0.706	+5.122	<.001	.008	3	1
BRCA	FAM25C →	+0.223	+5.020	.001	.009	3	1
UCEC	IGHV2-70 →	+1.920	+3.087	<.001	<.001	3	1
UCEC	LINC02340 →	+0.456	+2.689	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 558 associations by consensus.

RNU6-751P by CREB1 expression — LUAD

Explore this box plot interactively →