CREB1

Across TCGA pan-cancer cohorts, CREB1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CREB1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CREB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CREB1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where CREB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CREB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.744	<.001	12	view →
LIHC	All	II,III,IV	+0.622	<.001	8	view →
THCA	All	All	−0.444	<.001	8	view →
KICH	Female	All	−1.340	<.001	7	view →
CHOL	Male	All	+1.789	<.001	5	view →
STAD	All	II,III,IV	+0.552	.004	4	view →
ESCA	Female	All	+0.709	.027	2	view →
UCEC	All	All	−0.522	.012	2	view →
READ	All	III,IV	+0.415	.041	2	view →
LUAD	Female	II,III,IV	−0.338	.011	2	view →
PAAD	Male	All	+0.330	.011	2	view →
COAD	Male	All	+0.246	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CREB1–HNSC

Open the HNSC breakdown →