CRBN

Across TCGA patient cohorts, CRBN protein abundance is significantly associated with the RNA expression of many other genes, with 12,800 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CRBN-associated genes across cancer lineages are CBX7, CKAP4, and CEP55. Each is linked with CRBN in more than 5 cancer types. Because this analysis shows association rather than direction, both CRBN-to-partner and partner-to-CRBN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CRBN versus CBX7 in HNSC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRBN→partner) and Y-score (partner→CRBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CBX7 →	+0.633	+0.279	<.001	<.001	3	6
BRCA	CKAP4 →	-0.648	-0.216	<.001	.002	3	5
BRCA	CEP55 →	-1.132	-0.300	<.001	<.001	3	5
COAD	MYRIP →	+0.857	+0.285	<.001	<.001	3	5
HNSC	EIF1B-AS1 →	+0.465	+0.199	<.001	<.001	3	5
BRCA	GPD1L →	+1.148	+0.274	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,800 associations by consensus.

CRBN vs CBX7 — HNSC

Explore this scatter interactively →