CRBN

Across TCGA pan-cancer cohorts, CRBN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CRBN’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CRBN RNA is repressed in tumor relative to normal tissue. In most cancer types CRBN is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and LUSC are the cancer types where CRBN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRBN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.347	<.001	9	view →
THCA	All	II,III,IV	−0.456	<.001	9	view →
LUSC	All	III,IV	−1.578	<.001	8	view →
HNSC	Male	II,III,IV	−0.545	<.001	7	view →
UCEC	All	All	−1.074	<.001	6	view →
BRCA	Female	All	−0.375	<.001	6	view →
KIRC	All	II,III,IV	−0.272	.002	6	view →
KICH	All	All	−1.031	<.001	5	view →
LIHC	All	All	+0.215	.012	4	view →
KIRP	Male	All	−0.384	.001	3	view →
CHOL	All	All	+0.411	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CRBN–LUAD

Open the LUAD breakdown →