CRBN

Across TCGA patient cohorts, CRBN mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRBN-associated genes across cancer lineages are Annexin-1, Rictor_pT1135, and ER-alpha_pS118. Each is linked with CRBN in more than 1 cancer types. Because this analysis shows association rather than direction, both CRBN-to-partner and partner-to-CRBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by CRBN-low versus CRBN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRBN→partner) and Y-score (partner→CRBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.474	+2.341	.034	.019	3	2
UCEC	Rictor_pT1135 →	-0.102	-1.700	.019	.044	3	2
UCEC	ER-alpha_pS118 →	-0.457	-2.906	.002	.001	3	1
UCEC	FoxM1 →	+0.244	+1.700	.026	.044	3	1
UCEC	FOXO3a_pS318_S321 →	-0.106	-2.312	.044	.034	3	1
UCEC	INPP4B →	-0.332	-2.321	.015	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Annexin-1 by CRBN expression — UCEC

Explore this box plot interactively →