CRBN

Across TCGA cell cohorts, CRBN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,437 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRBN-associated GO terms across cancer lineages are Mitochondrial tRNA 3'-end processing, tRNA 3'-terminal CCA addition, and Positive regulation of pinocytosis. Each is linked with CRBN in more than 17 cancer types. Because this analysis shows association rather than direction, both CRBN-to-partner and partner-to-CRBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial tRNA 3'-end processing grouped by CRBN-low versus CRBN-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRBN→partner) and Y-score (partner→CRBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Mitochondrial tRNA 3'-end processing →	+0.183	+1.021	<.001	.004	3	18
LIVER	tRNA 3'-terminal CCA addition →	+0.177	+1.006	<.001	.005	3	17
LUNG_NSCLC_LUSC	Positive regulation of pinocytosis →	+0.154	+1.334	<.001	<.001	3	13
BREAST	Cardiolipin biosynthetic process →	+0.144	+0.796	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions →	+0.069	+0.898	.006	.001	3	12
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.071	+0.968	.004	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,437 associations by consensus.

Mitochondrial tRNA 3'-end processing by CRBN expression — LIVER

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