CRB2

Across TCGA cell cohorts, CRB2 mutation is significantly associated with the RNA expression of many other genes, with 731 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRB2-associated genes across cancer lineages are CCNG1, CCNI, and GCH1. Each is linked with CRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRB2-to-partner and partner-to-CRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNG1 grouped by CRB2-low versus CRB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRB2→partner) and Y-score (partner→CRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCNG1 →	+0.792	+3.043	<.001	<.001	3	2
LARGE_INTESTINE	CCNI →	+0.472	+1.936	.004	.005	3	2
BLOOD_Leukemia	GCH1 →	+1.298	+3.199	.007	.007	3	2
LARGE_INTESTINE	IPMK →	+0.675	+1.850	<.001	.006	3	2
LARGE_INTESTINE	SCOC →	+0.658	+2.364	.008	<.001	3	2
LARGE_INTESTINE	SNX7 →	+0.606	+3.330	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 731 associations by consensus.

CCNG1 by CRB2 expression — LARGE_INTESTINE

Explore this box plot interactively →