CRADD

Across TCGA patient cohorts, CRADD mutation is significantly associated with the RNA expression of many other genes, with 704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRADD-associated genes across cancer lineages are FTLP13, RNU6-1137P, and RNU6-1029P. Each is linked with CRADD in more than 1 cancer types. Because this analysis shows association rather than direction, both CRADD-to-partner and partner-to-CRADD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTLP13 grouped by CRADD-low versus CRADD-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRADD→partner) and Y-score (partner→CRADD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	FTLP13 →	+0.232	+4.925	<.001	.004	3	2
LUAD	RNU6-1137P →	+0.760	+5.217	<.001	.007	3	2
LUSC	RNU6-1029P →	+0.494	+4.532	<.001	.005	3	2
LUSC	GUSBP17 →	+0.130	+4.748	.005	.003	3	2
READ	MIR6165 →	+0.527	+4.421	<.001	.009	3	1
READ	PGBD4P2 →	+0.121	+5.257	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 704 associations by consensus.

FTLP13 by CRADD expression — READ

Explore this box plot interactively →